Zeyu Fu
Identity layer for research, software, and public tools

Zeyu Fu 付泽宇

Ph.D. Candidate · Single-Cell Computational Biology · Machine Learning

I build machine learning systems for single-cell genomics, spanning interpretable representation learning, neural ODEs, reinforcement learning, and graph-based modeling for cell-state dynamics, trajectory inference, and benchmark-ready analysis.

8 peer-reviewed papers highlighted on this homepage
8 published software projects with code or package distribution
4 public graph surfaces linked directly from the identity layer
Flagship journey

Identity → discovery → benchmark proof

The flagship triad gives visitors a deliberate path: verify the researcher and publications here, use SCPortal to choose the right single-cell route, then open LAIOR Benchmarks for focused model, dataset, and metric inspection.

Academic provenance Public graph continuity Benchmark microsite

About

Representation learning, dynamics, and decision-making methods for single-cell sequencing data.

See guided entry points

I develop machine learning methods for single-cell sequencing data (scRNA-seq and scATAC-seq), with published work spanning variational autoencoders, neural ODEs, reinforcement learning, graph neural networks, and hyperbolic geometry applied to cell fate analysis and representation learning.

Single-Cell GenomicsTrajectory InferenceVAENeural ODEReinforcement LearningGNNHyperbolic GeometryContrastive LearningClusteringFlow Matching

What this homepage helps visitors do

Understand the research arc

A concise read of recent publications, open-source releases, and the modeling themes connecting them.

Find the right public destination

The homepage routes visitors toward SCPortal for broad discovery or directly into a curated set of public tools.

Stay at overview level unless depth is needed

The page stays intentionally lightweight and identity-first rather than turning into a portal-scale index.

Research focus

Three recurring themes across the work

A compact map of the modeling directions that connect publications, software, and public app surfaces.

Match focus to software
01

Interpretable representation learning

VAE-family models, geometry-aware latent spaces, and stable embeddings designed for clearer clustering, visualization, and biological interpretation.

iVAE LiVAE CCVGAE
02

Dynamics and continuum modeling

Neural ODE and graph-enhanced methods for developmental trajectories, chromatin accessibility continua, and fate-transition structure in single-cell systems.

iAODE GNODEVAE CODE
03

Decision-aware single-cell analysis

Reinforcement learning and downstream evaluation utilities for branching, lineage focus, and targeted biological workflow support.

scRL scFocus mRNA Intersection

Publications

# Equal contribution   * Corresponding author   8 peer-reviewed papers

1

iVAE: An Interpretable Representation Learning Framework Enhancing Clustering Performance for Single-Cell Data

Fu, Z.#,*, Chen, C.#, Wang, S. et al. · BMC Biology 23, 213 · 2025

2

iAODE for Benchmarking and Continuum Modeling of Single-Cell Chromatin Accessibility

Fu, Z.#,*, Chen, C.#, Wang, S. et al. · Communications Biology · 2026

3

Correlated Latent Space Learning for Structural Differentiation Modeling in Single Cell RNA Data

Fu, Z.#,*, Chen, C.# · Computers in Biology and Medicine 198(A), 111115 · 2025

4

scFocus: Detecting Branching Probabilities in Single-cell Data with SAC

Chen, C.#, Fu, Z.#,*, Yang, J. et al. · Computational and Structural Biotechnology Journal 27, 2243–2263 · 2025

5

Lorentz-Regularized Interpretable VAE for Multi-Scale Single-Cell Transcriptomic and Epigenomic Embeddings

Fu, Z.#,*, Fu, J.#, Chen, C.# et al. · Frontiers in Genetics 16, 1713727 · 2026

6

scRL: Utilizing Reinforcement Learning to Evaluate Fate Decisions in Single-Cell Data

Fu, Z.#, Chen, C.#, Wang, S. et al. · Biology 14(6), 679 · 2025

7

GNODEVAE: A Graph-Based ODE-VAE Enhances Clustering for Single-Cell Data

Fu, Z.#,*, Chen, C.#, Wang, S. et al. · BMC Genomics 26, 767 · 2025

8

CCVGAE: A Centroid-Coupled Variational Graph Attention Autoencoder for Stable and Interpretable Single-Cell Representation Learning

Fu, Z.*, Liu, Y., Wang, J., Wang, S. · Array · 2026

Public graph

Curated Interactive Surfaces

Start with SCPortal for broad discovery, then move into a small, deliberate set of public destinations surfaced from the homepage.

Identity Discovery Focused workflows
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